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About Aspirin
NSAID stands for non - steroidal anti - inflammatory drugs ( medicine ) . Tissue inflammation cause increase secretion of Cox enzyme . Cyclooxygenase ( COX ) enzyme stir the secernment of prostaglandin , bradykinin , C respond protein and 5-hydroxytryptamine by wound epithelial and endothelial cells . These chemical causes inflammatory changes in injured and septic tissue . Prostaglandin and other inflammatory chemical substance when release in big amount during tissue paper inflammation also cause fever and pain in the neck . NSAID blocks the Cox enzyme resulting in decrease secretin of prostaglandin , bradykinin and serotonin . There are two type of Cox enzyme know as COX 1 and COX 2 . Aspirin inhibits COX 1 enzyme . Empirin 81 mg is widely used as a preventive medicament in patient suffering with coronary vascular disease . Aspirin is also used as an analgesic to deal pain and anti - pyretic medicinal drug to regale fever .
Alternative Name of Aspirin-
Aspirin is also known as Acetylsalicylic acid ( ASA ) .
Mechanism of Action of Aspirin
Empirin causes reversible inhibition of Cox enzyme 1 and 2 . Cyclooxygenase enzyme 1 and 2 are also known as COX 1 and COX 2 enzyme . Inhibition of COX 1 and 2 enzyme upshot in decreased output of prostaglandin and thromboxane ( TXA2 ) . Prostaglandin initiates pain sensation impulses when comes in link with pain receptors and sensory painfulness fibers .
Pain- Aspirin is used as an analgesic to treat modest to restrained annoyance that is triggered by lighting , joint diseases and injuries .
Fever- Infection and injuries increases prostaglandin level in blood . addition prostaglandin resets the temperature to high point , which follows increased metabolism and feverishness . St. Joseph diminish prostaglandin level in blood and also resets the temperature to normal physical structure temperature at brain snapper .
Inflammation- Harmful result induce by infection or trauma to soft tissue paper , bone and organ induces immune response and inflammation . instigative tissue activates cyclooxygenase enzyme , triggers increase profligate stream and trigger white-hot blood cells . Cox enzyme stimulates spiritual rebirth of arachidonic loony toons to prostaglandin within surrounding tissues . Inflammation and prostaglandin causes irritation of pain receptors and spunk fiber resulting in moderate to severe infliction . Aspirin facilitate to reduce the intensity of seditious tissue changes .
Kawasaki Disease – Kawasaki disease is an inflammatory disease of line vessels mostly seen in children . The profligate watercraft affected by inflammation are coronary arteries and blood vessels of extremities . symptom of Kawasaki disease is fever , conjunctival redness , ischaemic tenderness disease and death . Aspirin therapy helps to come down the seditious changes of blood vessels .
Pericarditis – Pericarditis is an non - infectious inflammatory disease of pericardium . The inflammation is intimately cover with aspirin .
Rheumatic Fever- Rheumatic febrility is a disease make by fever and dilate subcutaneous nodule as well as intense inflammation of heart ( carditis ) , joint ( polyarthritis ) , chorea ( vasculitis of basal ganglia ) . The acute inflammatory rheumatic feverishness is sharply treated with aspirin of corticosteroids .
Heart Attack – Heart blast is often cause by blockage or narrowing of coronary artery . acetylsalicylic acid helps as a blood cutting medicine and prevent rakehell coagulum formation that help to keep second heart attack .
Colorectal Cancer- write information intimate less phone number of colorectal cancer is observed in universe taking aspirin .
Pregnancy- Aspirin causes premature early occlusion of patent ductus arteriosus in baby if look at during third trimester . Aspirin may get brain haemorrhage in untimely baby if female parent is take up St. Joseph during third trimester .
pedigree thinning medicine- nullify claim while on other blood thinning medications ;
rye whiskey syndrome- former story of Rye syndrome ( progressive encephalopathy ) . The symptoms of Rye syndrome is confusion , raptus , regurgitation and loss of consciousness .
Dosage of Aspirin
Aspirin is uncommitted on the shelf and strength of pills are 81 milligram ( baby aspirin ) , 325 mg and 650 atomic number 12 . child Empirin 81 mg is used for bar of heart attack ( coronary arteria disease ) in patient suffering with coronary artery disease .
dose in adult is 375 to 500 mg acetylsalicylic acid 4 time a day . dose for kid suffering with disease like Kawasaki Disease is 5 mg / kg . 3 to 4 times a day .
Side Effects Caused by Aspirin
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Reference
St. Joseph for the bar of colorectal cancer
X. Garcia - Albeniz , MD , Research Fellowa and A.T. Chan , MD , MPH , Assistant Professor of Medicineb , * Best Pract Res Clin Gastroenterol . 2011 Aug ; 25(0 ): 461–472 .
Aspirin and Reye syndrome : a review of the evidence .
Schrör K1 . , Paediatr Drugs . 2007;9(3):195 - 204 .
