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Brand Names Of Most Commonly Used Benzodiazepines
History of Benzodiazepine
Physical Properties of Benzodiazepine
Pharmacological Action of Benzodiazepine
Metabolism of Benzodiazepine
Active Metabolites of Benzodiazepine
Drugs Triggering Prolonged Metabolism of Benzodiazepine
Inhibition of cyclic 450 enzymes by follow medicine prolong the metabolism of benzodiazepines .
Drugs Triggering Increased Metabolism of Benzodiazepine
Stimulation of liver enzyme by following medicinal drug go to rapid metabolic process of diazepam . gain pace of metamorphosis causes diminish drug levels and therapeutic effects .
Absorption of Benzodiazepine
When administered by word of mouth , it is rapidly absorbed by enteric mucous membrane and has a comparatively dissipated onset of action .
Bioavailability of Benzodiazepine
Plasma Protein Binding of Benzodiazepine
Plasma protein bind rate is very eminent for benzodiazepine . 96 to 99 % of the absorbed benzodiazepine binds to plasma protein . Thus only 1 to 4 % of the absorbed diazepam in the blood is usable for therapeutic ( medicative ) personal effects .
Peak Plasma Levels of Benzodiazepine
apex plasm point determines how soon a medicine will cause desire therapeutic effects . meridian plasma story follow administration through different route is as follows-
Distribution of Benzodiazepine
Blood Brain Barrier
It well crosses both the rip brain barrier and placenta . rip head roadblock control the flow of diazepam to brainpower and spinal cord .
Excretion
Dosage
Onset
Contraindications for Benzodiazepine
Age
Benzodiazepine should be order with care in following geezerhood group :
Drug Interactions
Adverse Effects of Benzodiazepine
Discontinuation of Benzodiazepine
Benzodiazepine discontinuation after short - term use does not make any side effects . But if Benzodiazepine is quit after long terminal figure use then side effects can be mild to severe in intensity . The ground for withdrawal symptoms is as follows-
Symptoms Of Anaphylaxis Reaction
Anaphylaxis ( Hypersensitivity or Severe Generalized Allergic Reaction)- Anaphylaxis is rarely seen following Benzodiazepine handling . Symptoms of anaphylaxis are as follows-
Symptoms Of Drug Allergies Other Than Hypersensitivity
Systemic Side Effects of Benzodiazepine
Benzodiazepine Dependence
Symptoms Of Benzodiazepine Dependence
Tolerance to Benzodiazepine
Symptoms of Tolerance
Physiological Changes Causing Tolerance
Withdrawal Syndrome
Mild detachment symptom after discontinuation of benzodiazepine is respect in few patient role address for short period . grave withdrawal symptoms are observed in patient treated with benzodiazepine for extend period , if abruptly discontinued . backdown syndrome may be short or prolonged as draw below-
Symptoms Of Withdrawal Syndrome
Symptoms of Drug Overdose
Treatment For Benzodiazepine Overdose
Overdose with alcoholic drink , opiates and/or other depressants may be fatal .
Pregnancy
Floppy Infant Syndrome – Persists for several hours after birth .
Benzodiazepine Withdrawal Symptoms
Milk
Immunoassay
Recreational Use
Legal Status in USA
