Can a Heart Infection Cause A Heart Attack?
Cardiovascular disease are the main suit of death in develop state . They stand for 20 % of global mortality in the reality . The intervention on traditional peril factors and the definitive treatment ofischemic heart diseasehave not managed to reverse the dramatic result of this disease . In late years , enquiry has focus on the etiopathogenesis ( aesculapian term that refers to the stemma of a disease and its mechanisms ) of coronary artery disease ( it is a vascular alteration characterized by temper , increased thickness and personnel casualty of snap of the arterial walls ) to find new alterative target that help us meliorate the control of atherosclerotic disease .
It has long been hump that the authoritative danger factor of ischaemic heart disease ( sexual activity , historic period , smoke , hypercholesteremia , hypertension , anddiabetes mellitus ) describe for only 50 % of clinically apparent shell of coronary artery disease . affected role with alike levels of cardiovascular risk know unlike courses of the disease and it is also known that the rates ofmyocardial infarctionand sudden last increase in winter and after epidemic of grippe . All these finding have support the theory that infections could condition an increase endangerment ofatherosclerosis .
In addition to all these consideration , we must bear in mind that the variability of each individual can condition a unlike response to these aggressions .
harmonize to the inflammatory reaction that triggers the person , along with the immune answer to the different pathogens , there will be a bully or lesser susceptibility to the formation of coronary artery disease due to an infectious stimulant .
In the Book of Genesis of atherosclerosis , different microorganisms have been call for . Of all of them , Citomegalovirus , Chlamydia pneumoniae , and Helicobacter pylorus are the ones on which there is greater grounds .
Atherosclerosis and Helicobacter pylori
This bacterium shack in the cells of the stomachic mucosa and is transmitted by a fecal - unwritten mechanism . It is present in much 100 % of duodenal ulcer and in 60 % of stomachal ulcers . H. pylori transmission is unremarkably acquired in puerility and antibodies against it will persist until later in life , so the preponderance of antibodies against Helicobacter in the general universe is very in high spirits , around 40 % at 50 old age old .
Numerous studies have confirm an tie-up between irrefutable serology against H. pylorus and atherosclerotic disease . Most of them have been perform in patient role with classic ischaemic heart disease and some on cerebral coronary artery disease .
Atherosclerosis and Citomegalovirus
The first infectious agents related to atherosclerosis were viruses , and of all of them , the folk of herpesviruses .
It can be transmitted through the fecal - oral , unwritten - oral or parenteral itinerary . It is believed that their innate home ground is leucocyte , although this is not well established . The infection in immunocompetent individuals remains in a latent land throughout spirit , although it may undergo reactivation , symptomless in most cases . The preponderance in the general universe is very high ; more than 50 % of the population over 35 days of age has antibodies against the virus , and as these eld increases , these figures rise to 70 % in those over 70 years . CMV infection is correlate with a low socioeconomic status , with immunosuppression states and with age .
Most studies show a positive association between CMV infection and atherosclerosis .
Atherosclerosis and Chlamydia pneumoniae
This bacteria is transmitted through respiratory secretion and is believe to persist in spite of appearance alveolar macrophage . It is the second pathogen causing atypical pneumonias , responsible for for 10 % of cases . The primary contagion by C. pneumoniae usually occurs at former ages of life and reinfections are extraordinarily frequent . about 50 % of those over 50 years have positive serology against C. pneumoniae and its prevalence correlates with age , socioeconomic condition , smoking habit and periodical epidemics .
The result of epidemiological studies show a hard association between positively charged serology against C. pneumoniae and coronary artery disease .
Also say :
