Liver pit is also recognize as liver fibrosis , which is due to progressive liver inflammation and liver mobile phone death in continuing liver diseases . Liver scarring appears when liver tries to remediate its damage cells through deposition of unexampled collagen fibre . This dethronement of indemnify tissue paper solvent in scarred tissue or fibrous tissue paper formation . This exaggerated combat injury healing response interferes with normal liver subprogram . Liver is supposed to have over 500 functions include protein synthesis , destruction of old RBCs , detoxification and metamorphosis of chemical substance and drug along with hormone regulation and digestion of fats wait on by the production of gall , to name a few .
What Are The Causes of Liver Scarring?
There are various causes of liver scarring , but the most common causes include inveterate alcoholism , inveterate viral disease ( hepatitis B and C , HIV ) and/or fatty liver . Other causes of liver scarring may include hemochromatosis , Wilson ’s disease , cystic fibrosis , bilious atresia , glycogen entrepot disease , Alagille syndrome , autoimmune hepatitis , basal bilious cirrhosis of the liver , infection ( bilharziasis ) , basal sclerosing cholangitis and/or medication such as methotrexate .
Symptoms and Causes of Liver Scarring
Generally liver scarring does not present with any sign of symptom in the early stages , as the symptoms do not usually come about until grave liver price has occur . The signs and symptoms when present include weakness , flatness , easy bruising and haemorrhage , pruritis , jaundiceand in its advanced stage when progressed into cirrhosis might also includeascites , nausea , vomiting , weight loss , deprivation of appetite , swell up of legs , dilate nervure in the esophagus and upper stomach , confusedness , excessive sleepiness / drowsiness and comatoseness .
The Stages of Liver Scarring
The stages of liver pock regulate the degree of legal injury to the liver . The body process or the prediction of how the fibrosis is progressing is done based on a pop scoring scheme called the METAVIR scoring system . The fibrosis stages range from F0 to F4 . F0 stage show no grounds of scarring , F1 microscope stage is the stage of portal fibrosis without any septa shaping , F2 phase has portal fibrosis along with few septum formation , F3 point is the stage of various septum , but without any cirrhosis of the liver , F4 stagecoach is the stage of liver fibrosis . The ripe soma of liver fibrosis / scarring is the F3 and F4 microscope stage . Fibrosis when not managed in the initial stages will lead to cirrhosis . Liver cirrhosis is a inveterate progression of fibrosis ( scarring ) of healthy liver tissue lead to functional deterioration of the liver .
Can a Scarred Liver repair itself?
Can marred liver be repaired or not depends on the stage the fibrosis is in . In the initial stage , the marred liver can be repaired and avoided from advance into advanced liver damage by removal / bar , treatment and healthy diet . When causative factors like inveterate hepatitis , chronic dipsomania and non - alcoholic liver disease are not remove , liver fibrosis go on into cirrhosis . At this spot the scarring of liver can not be furbish up . It can only be prevented from further forward motion into liver failure and ultimate death .
diagnosing is establish on physical testing , typical symptoms , blood test , liver function psychometric test ( measuring level of liver enzyme and determining the liver subroutine and presence of equipment casualty to the liver ) . Other tests used are ultrasound , elastography , magnetic resonance elastography and biopsy .
There is no specific treatment to bring around liver injury due to liver scarring and once progressed it can not be reversed and will lead to liver cirrhosis . However , treat the underlying causal agency may prevent further procession of the disease , thus avoiding liver cirrhosis of the liver , liver loser , and death . Fibrosis from excessive alcoholic beverage can be keep from worsening by intoxicant abstention and prescription medication such as naltrexone and acamprosate and attend support computer programme such as AA ( alcoholics anonymous ) . Fibrosis related to viral hepatitis is treated with antiviral drugs and also with interferon . Autoimmune hepatitis is treated with corticoid ; elemental biliary cholangitis is deal with ursodiol that slows liver damage . Wilson ’s disease is treated with penicillamine , which chelate excess cop store in the trunk .
Liver fibrosis / scar can be further prevented from progression by eat up a level-headed and well balanced diet and avoid foods and drinks cause liver damage .
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