Uterine fibroid are the most common benign pelvic tumors in char . It fall out in 20 to 40 % of charwoman in reproductive age . They can be clinically evident in 20 to 25 % of the cases ; the greatest peak of presentation takes place in the 4th to 5th decades , presenting up to 80 % of the pathology specimens of the surgically resected uteri , independently of the preoperative diagnosing . It is also jazz as uterine leiomyomatosis , fibromyomas , leiofibromyomas and fibroleiomas .
They are composed of large amounts of extracellular matrix ( collagen , fibronectin and proteoglycans ) . Collagen eccentric I and II are present in abundant amounts , but the collagen fibers are mold irregularly and topsy-turvy , similar to the keloid formation .
There is evidence that they have a genetical cornerstone and that their growth is related to genetic sensitivity , hormonal influence and several growth factors .
Can Fibroids Cause You To Gain Weight?
Uterine fibroids cause an growth in the size of it of the aforementioned pipe organ , originating weight unit amplification . The large size of some tumors has been depict with astonishment over time . The largest case of a uterine fibroid tumor was described by Hunt in 1888 as a determination at a necropsy , with the “ awe-inspiring ” weight of 63.5 kg . This distinctly shows that fibroid can get to clear weight .
It is estimated that only 20 to 50 % of women with one uterine fibroid or more experience symptoms that may be attributed directly to the fibroids itself . The symptom vary and include abnormaluterine hemorrhage , pelvic bother , pelvic pressure , slim down bladder electrical capacity , constipation , and procreative disfunction .
The most common symptom is unnatural uterine bleeding . symptom usually correlate with their emplacement , number , size of it or with some concomitant degenerative modification .
-An step-up of the size of the airfoil endometrial area .
-Increased vascularity and vascular flow of the uterus .
-Interference with normal uterine contractility .
-Endometrial ulcer of the submucosal fibroids .
-Compression of the venous plexus with the myometrium .
fibroid tumor undergo regression after change of life , which is accompanied by atrophy of the endometrium allow the uterine haemorrhage to stop .
Symptoms of Pelvic Mass : The subserosal fibroids are the most related to this symptom . The size of the myomatous womb is described in menstrual weeks , as well as in a significant womb .
A myomatous uterus 12 to 20 weeks in size can be palpated on abdominal interrogation . Pelvic pressure appears when the uterus increases of size . As the uterus grow , pressure on conterminous organs , specially the urinary tract and rectosigmoids , is accentuated . The demonstrations associated with the urinary tract include frequency urinary output obstruction and ureteral obstruction with hydronephrosis . Constipation or tenesmus may be lowly to fibroids in the posterior bulwark , which exert pressure on the rectosigmoid .
Pain : It is not a frequent symptom , and it is normally associated with the torsion of a pediatric fibroid tumor , cervical dilatation by a submucosal fibroids , protruding from the lower uterine section , or by a red degeneration associate with maternity .
sterility : Uterine myomatosis is associated with sterility in 5 to 10 % of cases . The intramural and subserosal fibroids tend to produce dandy procreative dysfunction . The suggest mechanism through which decrease fertility include :
-Alteration of the endometrial contour that interferes with the implantation .
-Aggregation and disfiguration of the uterine cavity that intervene with sperm exaltation .
-An anatomic overrefinement that repress access to the cervix .
-Altered uterine contracture .
-The perseveration of intrauterine hemorrhage or clot interferes with nidation .
-Subsequent fibroids may interfere with the relationship between anatomic tube - ovarian , and the tubal ostium may be distorted or block .
Fibroids are clearly link with exposure of oestrogen and circulating Lipo-Lutin .
In fact , they are rarely respect during pubescence , and they are more prevalent during the reproductive years , with regress after menopause .
The danger factor associate with this pathology are age , parity , ethnicity , hormone switch therapy , endogenous hormonal element , weighting , diet , exercise , kinfolk history , pregnancy , weave injury andsmoking , among others .
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