Malaria is a sponger - borne disease make by the bite of a mosquito through its spit . Malaria can cause substantial illness in tropical and endemic regions . Many Treatment pick are available to control the disease . Antimalarial drug have many contraction and a person can develop resistivity against them in some geographic areas especially in endemic areas . It was assumed that antibiotics are ineffective against malaria . But , recent studies reveal that some antibiotics have potentiality to treat and keep malaria .
Can Malaria Be Treated With Antibiotics?
late sketch unwrap that antibiotics are very effective for treatment and bar of malaria . In many cases , it has been watch over that drug resistor has been developed in many geographic regions . The disease has been bring down constant health problems despite uses andchemotherapies .
The antibiotic have their action on the apicoplast of the sponger . Apicoplasts are cellular Hammond organ involve by parasites to go in other cells of the emcee being . They throttle the growth and reproductive memory of sporozoite in the liver . Thus , antibiotics are the well option for therapeutic management of hard and complicated case of malaria . Antibiotics are prescribe in combination with antimalarial drugs to handle malaria .
Some of the antibiotics that can be used to handle malaria are following-
Co-trimoxazole
The combining of trimethoprim and Gantanol is love as Co - trimoxazole . late studies let out this compounding is very efficient to treat malaria in semi - resistant children . This drug is recommended by WHO for the treatment of opportunistic infections like malaria inHIVpatients worldwide . It is good preventive medicinal drug against malaria in kid , adult , HIVpositive patient and significant fair sex due to its efficacy and safety visibility .
Quinolones
Quinolones are the semisynthetic compounds that can be used as the antimalarial antibiotic drug . It has been marked that quinolones direct the gyrase enzyme of the malarial parasite ( the enzyme is responsible for its increment and replication ) , thereby controlling malaria . Ciprofloxacin ( a quinolone ) has increased anti - malarial bodily process against P. falciparum . Quinolones target various stages of malarial parasite ( P. vivax and P. ovale ) life oscillation in liver and blood . Several researchers are still ferment to discover the best antimalarial drug to order with quinolones to treat malaria .
Tigecycline
It is extremely effectual in cases of severe and complicated malaria especially against P. falciparum when administered intravenously . In drug - resistant country , it can be given in compounding with antimalarial drug for complicated malaria . It is not recommended for treatment of malaria in children and pregnant women .
Mirincamycin
late sketch show this drug can be used in combination with fast - acting malarial drugs to hold in the growth of malarial parasite in RBCs .
Ketolide Agents
Ketolide agents possess antiplasmodial activeness that can retard the DNA rendering process in Plasmodium . Further research has been in advance to study this antibiotic for restraint of malaria .
Fusidic Acid
Fusidic acid is a steroid hormone antibiotic drug primarily used for suppression of Staphylococcus bacteria . It has displayed antimalarial activeness against P. falciparum parasite by inhibiting sponger ’s activity and growth in the first and 2nd cycles/second of infection in RBCs . However , it ’s efficacy is still to be give away in succeeding inquiry works .
Thiopeptides: Thiostrepton and Nocathiacin
Thiopeptides too own antimalarial property . It can subdue the growth of P. falciparum by its power to kill gametocytes . It can interfere with RNA retort of P. falciparum . Further studies are in full flow to facilitate the drug as a possible music to process malaria in the futurity .
Conclusion
The use of antibiotic has been reserved for affected role who have developed severe and complicated malaria or patients who have extra risks with uncomplicated malaria . Major inquiry studies are in pipeline to prove the efficiency of antibiotics for effective treatment of malaria .
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