Can Pneumonia Lead To Pulmonary Hypertension?
Pulmonary hypertension ( PH ) is determine as the front of a PAPm ( mean pulmonary pressure ) greater than 25 millimeter Hg measured by cardiac catheterisation .
Pulmonary high blood pressure is seen comparatively oftentimes in intensive care units . Despite this , its transcendency has only recently been recognized .
It Manifests Itself In Two manikin : as the exasperation of a pre - existent circumstance or as a de novo operation that complicate an incisive status ( pneumonia , nub bankruptcy , among others ) .
In this last situation the diagnosing is not easy , since the values of imperativeness that are detected are not very high , because the right heart ventricle is a bedchamber of volume , with thin wall and has no possibleness of generating values not bad than 50 mm Hg systolic pressure or 40 mm Hg mean pressure . national with high values have some previous disease that has conditioned correct ventricle so that it can sustain higher pressures .
The Pathogenesis Of Acute Pulmonary Hypertension Is fundamentally Based On :
PVR Depends On Several element : Extrinsic compression produced by intraalveolar pressure and intrapulmonary pressure , remodeling former participation of the vascular rampart , favored by the show of smooth musculus in the wall of the belittled distal artery of the pulmonic vascular Sir Herbert Beerbohm Tree , the organisation of microthrombi in the light and the activity of mediators such as nitric oxide ( NO ) and prostacyclines of vasodilator natural action , endothelin-1 , thromboxane and serotonin , pressor effect , in add-on to others still under study .
All forms of pulmonary high blood pressure can present in an incisive patient role . The differential diagnosis must always be study ; the key to diagnosis is in obtain a exhaustive medical history , although finally , in all case , when pulmonic hypertension compromise the right heart ventricle ( RV ) by decompensating the affected role , the behavior is go to be the effort to diminish the pneumonic pressing and carry on the RV .
The grandness of pulmonic high blood pressure usually goes unnoticed or indispose in a patient who is suffering from another serious sickness and who may even be in mechanical ventilation . When RV function devolve , the diagnosing is more unmanageable because lung pressing progressively minify and what at first pot can be interpret as an advance it may actually be the beginning of the circulatory prostration .
On the other hand , pneumonia is an knifelike respiratory disease , of infectious stemma , which compromises the pulmonary parenchyma have by the intrusion of infective microorganisms ( virus , bacterium , fungus and parasites ) .
Adult community pneumonia has an acute evolution , characterise by via media of ecumenical term , fever , chills , cough , mucopurulent expectoration and respiratory distress ; associated in the physical examination for tachycardia , tachypnea , pyrexia and focal house in the pulmonary examination . The chance of a affected role with respiratory symptoms of receive pneumonia depends on the preponderance of disease in the environment where it come and the manifestations .
The Diagnosis Of Pneumonia Is Clinical - Radiographic : the clinical chronicle and forcible examination suggest the front of a lung transmission , but the diagnosis is confirmed when the presence of infiltrates is demonstrated on the chest radiograph . The clinical and Chest x - ray of light findings do not tolerate to predict with foregone conclusion the etiologic federal agent of lung infection ; the symptoms , signs clinical features and radiographic finding overlap between the unlike causative agents ( authoritative and atypical bacteria , respiratory viruses ) .
The chest of drawers radiography allows confirming the clinical diagnosing , set up its positioning , extension and severity also makes it possible to differentiate pneumonia of other pathologies , observe possible complication , and may be utile in monitor high-pitched - risk patients .
Conclusion
pneumonic hypertension has been associated with respiratory diseases , such as idiopathic interstitial pneumonia and chronic clogging pneumonic disease . Non - specific interstitial pneumonia is a pathological entity of idiopathic interstitial pneumonia , of which there are no data or publications associated with PH .
Although some forms of pneumonia have been related , they are not likely a causa of pulmonary hypertension .
Also Read :
