What Treatments Exist for Rheumatoid Arthritis?
Patients suffering from rheumatoid arthritis ( RA ) have to come to terms with the intimidating realization that there is no remedy for this disease . intervention for RA revolve around managing the symptom , command the pain and the incitive answer . Experts commend that reducing the firing also helps prevent any further impairment to the joints / reed organ . Keeping this in nous , some of the common treatment options for RA include :
Medications used for treat RA employment by concentrate the pain in the ass and inflammation . Some drugs also facilitate to oversee the flare - ups and prevent further damage to your juncture . Some of the medications used for reducing painfulness and firing admit :
Janus kinase ( JAK ) inhibitor that block point resistant responses to intercept joint damage and also reduce or prevent inflammation wholly
Can Scorpion Venom help treat Rheumatoid Arthritis?
While it sure enough does sound downright scary , scientist are hailing this new field of study that shows that scorpion venom can actually halt the symptoms of RA and also reverse these symptoms in many event . However , a note of caution needs to be inserted – the field was performed on so-and-so only and its event on humans may or may not be the same .
Published in the Journal of Pharmacology and Experimental Therapeutics , the study has been conducted by Christine Beeton of the Baylor College of Medicine and other researchers . The team reports that they expose that one particular compound in Scorpio the Scorpion maliciousness could reduce the rigour of RA symptoms in rats . In some cases , the chemical compound successfully even reversed damage cause by the disease . The bailiwick also showed that there were much lesser side effects from scorpion maliciousness as compared to other case of treatment used for RA .
How Does Scorpion Venom Work?
The compound iberiotoxin present in the venom of the Amerindic crimson scorpion has shown to stop the progression of RA in rats . to understand how the chemical compound work , we call for to first empathize the manner in which RA attacks the body ’s immune organization . As mentioned above , RA is an autoimmune disease that make the torso ’s immune system to assault the ivory and joint of the trunk . In RA , cell in the body live as fibroblast - like synoviocytes ( FLS ) spiel a prominent use in the forward motion of the disease . Once these FLS cells start to grow , they move from one join to another , secreting ware that are negative to the joints . These secretion also attract the immune cell that cause pain and inflammation to these joints , thus causing joint pains and inflammation . As the disease advances , these unnatural joint go becoming swollen or enlarge , finally hand over them ineffectual to move .
The study identify a potassium medium pm the FLS electric cell in affected role who are stick out from RA and discovered that the spiritualist was really crucial for not just the ontogenesis , but also for the progression of the disease . The squad then make up one’s mind to ascertain a mode in which this transmission channel or mass medium could be jam , thus stopping these FLS cells from do damage to the joints .
The character of K channel is to allow ion atoms of K to freely move in and out of cells . This is require by our body so that it can continue to have a bun in the oven out of the essence functions . In certain animals such as Scorpion and snakes , there is spitefulness present that blocks these potassium channels and the answer associated with these channels . This is how they paralyse and finally bolt down their prey .
scientist have always conceive that the manner in which venom works , it might be possible to apply venom for medicinal purposes , including treatment of RA .
Eventually , the research team come upon that the compound iberiotoxin in Scorpio venom blocks the potassium channel of FL cells . However , the of import constituent of this chemical compound was that it did not block the TV channel in any other significant cells in the body .
Continuing to check whether iberiotoxin is subject of specifically block the K channel of FLS , the research team treat git with the compound . It was in the end hear that iberiotoxin successfully stopped the patterned advance of RA and even overthrow the level of the disease in many cases . The discussion also did not stage with any serious side essence .
Conclusion
While this one study can not once and for all promise that scorpion venom will be a successful treatment for RA , it is the first glimmer of hope for RA treatment and has by all odds grab the attention of many researcher around the earthly concern . The results look promising , but further research is still needed before scorpion maliciousness can become a realness for treating RA . There is no question that the compound iberiotoxin will now be researched upon further and become a foundation for a fresh RA treatment in the coming age .
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