Can You Reverse Autoimmune Hepatitis?
It is of import that all patients with autoimmune hepatitis are evaluated by a Doctor of the Church who particularise in liver diseases . They should have follow - up with analysis , and ultrasound if appropriate . They must precede a levelheaded life . Healing or reversing the autoimmune hepatitis is rarified . More than 70 % of patients want immunosuppressive treatment for living .
Autoimmune hepatitis is a liver disease originate by a dysfunction of the immune organisation that causes it to attack and destroy the liver cell . In other words , the Defense Department mechanism of the organic structure react against the liver cells .
This is a rare disease , it usually presents as a terrible acute hepatitis , chronic hepatitis or cirrhosis . This hepatitis becomes chronic and can not be prevented .
The causes are not known , but it is believe that there may be a genetic predisposition , since it often affect people with relation who have autoimmune diseases . It has been suggested that some toxic or microbic environmental agent could be the precipitating factors of the disease oncoming . It has been implicate viruses that do different disease such as measles or kiss disease , as well as the hepatitis A virus . Also some drug , including some that are used to reduce cholesterin such as pravastatin and atorvastatin . The activity of some herbal products has also been postulated . However , there is no certain grounds that they are responsible for the disease .
Autoimmune hepatitis occurs principally in girls and young woman ; it affect the distaff sex in 70 % of cases . The disease can begin at any age , but is more frequent in adolescents or young adult . The most common symptoms of autoimmune hepatitis are fatigue , inaccurate abdominal discomfort , joint painful sensation , pruritus ( itch in the body ) , jaundice ( xanthous colouration of skin and mucous ) , hepatomegaly ( enlarged liver ) and wanderer nervure ( venous dilatations ) in the skin .
When patients have liver cirrhosis , they may also have ascites ( fluid in the abdominal cavity ) and hepatic brain disease ( land of genial confusion ) .
The diagnosing is based on clinical and analytical data point and also on liver biopsy in which there are generally alteration very suggestive of the disease . For diagnosing the disease it is vital the presence of antinuclear antibodies , such as anti - bland muscle or Liver kidney microsome case 1 ( LKM-1 ) . These last antibodies occur in autoimmune hepatitis eccentric 2 , which is very rarified , predominantly in children and with the need to maintain immunosuppressive treatment almost indefinitely . There is also an addition in Vasco da Gamma globulin .
The bulk of affected role respond well to immunosuppressive therapy . When this happens , the selection of the disease is very just , and depends on the severity of the disease at the time of diagnosis . Patients who already have cirrhosis when the disease is diagnosed have a worse medical prognosis . Survival at 10 years of patients without handling is approximately 10 % .
The finish of the treatment of autoimmune hepatitis is to cure or assure the disease . Between two and three tail of patients tend to anneal liver occasion tests .
The intervention of autoimmune hepatitis comprise in the administration of immunosuppressive drug either with prednisone or in combination with azathioprine . Medical discussion has shown to be in force on the disease symptom , liver use mental testing and increase survival in the majority of patient . Normally , treatment with 60 mg / 24-hour interval of prednisone or at a Lucy in the sky with diamonds of 30 mg / sidereal day of prednisone a Clarence Shepard Day Jr. along with 50 to 100 magnesium / day of azathioprine is started .
This discourse should be continued for several hebdomad until the disease is put over , at which sentence the doses of Meticorten are progressively reduce to the minimum necessary to keep the activity of the unconscious process under ascendance . The suspension of discourse extend the risk of relapse , which can be unmanageable to control . The drawback of using Orasone at in high spirits doses for a long metre is the appearance of serious side effects , such as high stemma insistency , diabetes , bone red and cataracts . Low sexually transmitted disease of prednisone are often used in combination with azathioprine . Not all patient with autoimmune hepatitis respond to treatment with prednisone . In these cases other drugs ( budesonide , cyclosporine , tacrolimus or mycophenolate ) are used .
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