Around the world , meg of people are affected by the Hepatitis C virus every twelvemonth . Hepatitis C is an infection that attack the liver and causes fervor . The hepatitis C virus does not cause any symptoms until the time it reaches a continuing microscope stage ; therefore , many hoi polloi stay incognizant that they have contracted the Hep - C computer virus . The Hep - C virus spreads through physical structure fluids or through the rakehell of an infected person , thereby disperse normally through sexual intercourse , share needles and drugs , during the birthing process where a female parent can die it on to a child , etc . If chronic hepatitis C is not treated , then it can eventually lead to liver damage and even damage other organs as well . There are many different types of hepatitis C handling that work by pass the computer virus from the body . The organic evolution of hepatitis C treatments has come rapidly ; and today , proteolytic enzyme inhibitor and antiviral drugs are the two most common forms of treatment for hepatitis C. rent us take a look at how these discourse options liken against each other .
Protease Inhibitors vs. Antiviral Drugs for Hepatitis C Treatment: Differences Based on Definitions & their Action
Antiviral Drugs for Treating Hepatitis C
Antiviral drugs are a family of medications that are used for treating viral infections . These drugs work by conquer the maturation of the Hepatitis C computer virus itself , rather than destroying the virus .
To treat hepatitis C , the usual discourse that has been used for many yr is a combination of two antiviral medication . These drug are specifically design to get disembarrass of the HCV . Pegylated interferon ( PEG ) and ribavirin are the two antiviral drugs that are used to treat hepatitis C. While PEG is dispense as a weekly shot , ribavirin pills postulate to be taken twice a Clarence Day . This antiviral therapy for Hepatitis C discourse takes around six months to a year to finish . The therapy is sometimes also touch on to as PEG / riba .
Protease Inhibitors for Treating Hepatitis C
Protease inhibitors are also a course of instruction of antiviral drugs itself . However , they take issue from the common antiviral drug in the fashion in which they ferment . proteinase inhibitor prevent the computer virus from replicating by hold to other viral peptidase . These are a newer class of drug that also occlude the proteolytic cleavage of protein precursor . These protein herald are what the Hepatitis C virus requires for producing more infectious viral subatomic particle . These drug are now widely being used for the treatment of hepatitis C andHIV / AIDS .
Protease Inhibitors vs. Antiviral Drugs: Differences Based on Side Effects
Side Effects of Antiviral Drugs for Treatment of Hepatitis C
PEG / riba treatment have austere side effects . These may include :
Side Effects of Protease Inhibitors for Treatment of Hepatitis C
Some of the common side event of protease inhibitors include :
Protease Inhibitors vs. Antiviral Drugs: Comparing New Developments
Development of Antiviral Drugs for Treating Hepatitis C
Since 2011 , there has been an improvement in the development of antiviral drug as a new class of drugs was introduced know as verbatim - action antiviral . These direct - act antiviral work on by destroying the computer virus directly by interfering with the virus ’ ability to reproduce and circulate in the body . These are alike to the working mechanism of protease inhibitors , but proteolytic enzyme inhibitor are a class of drug further advanced than unmediated - acting antiviral . It has also been view that verbatim - acting antivirals are more effective in cure more types of hepatitis C when compared to PEG / ribavirin alone . Interferon and ribavirin were typically found to be effective against eccentric 1 hepatitis C , whereas , these direct - act as antiviral drug are indicate to be effective against most types of hepatitis C. Similar to protease inhibitors , these direct - act antiviral drug also have lesser side effect .
There are three classes of direct - acting antiviral that have been approve till date . These include :
A combination of these three drug is used for treating HCV , depending upon which genetic constitution of the disease the affected role is suffering from . Due to the increased effectiveness of verbatim - represent antivirals and lesser side effects , direct - acting antiviral have now become the standard for hepatitis C handling , particularly for people who have reached the chronic stage of the disease already . In some case , the PEG / riba therapy is still used , but in combination with direct - represent antivirals only .
Development of Protease Inhibitors for Treating Hepatitis C
Protease inhibitors are a young generation of unmediated - roleplay antiviral drug . There are currently two type of protease inhibitor drugs available for the treatment of hepatitis C. These admit simeprevir ( brand name Olysio and Sovriad ) , and paritaprevir . Both of these drugs are used in combination with other medications , bet on the type of hepatitis C the patient is bear from . The first genesis peptidase inhibitors , telaprevir and boceprevir , are no longer used in the treatment of Hepatitis C. Similar to the first generation antiviral drugs , proteinase inhibitor are also know to be more effective in treat genotype 1 of Hepatitis C. The heavy welfare of using protease inhibitors is that they cause less severe and few side outcome .
Conclusion
There is no ‘ one - sizing - fits - all ’ pick when it make out to treatment options for hepatitis C. Since there are many genotypes of the disease , the treatment has to be tailor accordingly . It is important to understand that your doctor will define the honest trend of treatment for you ground on several cistron , the most crucial one being which genotype of hepatitis C you have . Not all drugs forge on all the genotype of hepatitis C. The medication that will be selected for you by your doctor will also bet upon the extent of liver scarring ( cirrhosis of the liver ) or liver damage you have . Research is move quickly in the field of hepatitis C treatment and as researcher develop fresh intervention , your Doctor of the Church may exchange the combination of your medications accordingly .
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