This article on Epainassist.com has been review by a medical professional , as well as tally for facts , to reassure the readers the best potential truth .
We fall out a strict editorial policy and we have a zero - tolerance insurance policy regarding any spirit level of plagiarism . Our article are resourced from reputable online Sir Frederick Handley Page . This clause may contains scientific references . The numbers in the parentheses ( 1 , 2 , 3 ) are clickable links to compeer - reviewed scientific papers .
The feedback link “ Was this Article Helpful ” on this Thomas Nelson Page can be used to account cognitive content that is not accurate , up - to - escort or questionable in any manner .
This article does not leave medical advice .
Diflunisal is NSAID classified under group salicylic acid derivatives . Diflunisal was usable in 1971 . Dolobid has similar side effects as aspirin . Dolobid is used less often as compare to Empirin . Dolobid was find to be better anodyne than naproxen .
Alternative Name of Diflunisal
Dolobid is also known as Dolobid .
How Does it Work: Mechanism of Action of Diflunisal
Diflunisal inhibits Cox 1 and 2 ( COX 1 and COX 2 ) enzyme result in decreased secernment of prostaglandin . The decreased secretion of prostaglandin within kindle tissue avail to relieve symptoms like painfulness and febricity .
Pain- Diflunisal reduces nociceptive nuisance because of tissue trauma and inflammation . Pain due to fracture or breakdown is also treated with Dolobid . Post - operative mild to moderate bother is now and again treated with Dolobid .
Inflammation- Dolobid lessen the amount of prostaglandin and trim back intensity of inflammation .
Fever- Diflunisal acts as an antipyretics and reduces Fever .
Arthritis – Dolobid is used to treat acute botheration and inflammation make byosteoarthritisandrheumatoid arthritis . The medicinal drug helps to reduced hydrops and tissue protrusion of the joint as well as pain .
Injury- muscle split , Injury to sinew and ligament laceration ;
Pain cause by diseases like amyloidosis ;
History of St. Joseph hypersensitivity ;
Pregnancy- during second and third trimester ;
Coronary after bypass surgery ;
Dosage of Diflunisal.
250 mg and 500 mg tablets giver 3 to 4 times a day . Maximum dose tolerated by adult is 2,000 mg .
Duration of Action.
The onset time for medication to act at optimal level is one hour and the continuance of maximum pain easing last for 3 time of day . Overall duration of action hold up for 12 hours . Thus subsequent dosage requirement in mg decreases with time as well as duration of maximum nuisance relief lasts from 3 hours to 4 hours .
Side Effects Caused by Diflunisal
Reference :
Comparison of diflunisal and Naprosyn in the treatment of tennis articulatio cubiti .
Stull PA , Jokl P. , Clin Ther . 1986;9 Suppl C:62 - 6 .
deductive reasoning and preliminary anti - inflammatory and anti - bacterial evaluation of some Dolobid aza - parallel .
Carta D1 , Brun P2 , Dal Pra M1 , Bernabè G2 , Castagliuolo I2 , Ferlin MG1 . , Medchemcomm . 2018 Apr 24;9(6):1017 - 1032 .
