What is Factor V Deficiency or Owren’s Disease?
There are numerous diseases that only affect the human profligate . Those diseases that only regard the most important liquid state in the human beingness which is stock , are called hematologic diseases . One of the rarefied haematological diseases this clause will be devote to is Factor V deficiency or Owren ’s Disease . This extremely rare hematologic disorder either results in prolonged or obtuse curdling of the blood after an injury or surgical procedure .
Just like the other name of Owren ’s disease suggests , this sickness has to do something with a protein called Factor V. This protein is also bang under the name accelerator factor . Proaccelerin is a protein that is made up in the liver . This protein helps in the rebirth of factor II into thrombin . This conversion is an crucial part of the blood clotting process . However , if there is not enough of Factor V , your blood will curdle with a peachy trouble . gene V deficiency or Owren ’s disease was describe by a well - known and appreciated aesculapian doctor Paul Owren . Thus , this disease is called Owren ’s disease . Dr. Paul Owren had first described this malady in 1943 in one Norwegian affected role .
Factor pentad lack or Owren ’s disease is so rare that is has been count on that it will affect only one person per million people . What also need to be tell about Factor Little Phoebe deficiency or Owren ’s disease is that it is a genetic disorderliness that is inherit in an autosomal recessionary way . This entail that both of small fry ’s parents need to have Factor five deficiency or Owren ’s disease to fade it onto their nestling and the future offspring . Factor V deficiency or Owren ’s disease affects both the women and the humans as .
What is Factor V in Blood?
cistron V is a protein that acts as a catalyst . It accelerates the cognitive operation by which prothrombin becomes converted to thrombin , which is an essential and initial step in the formation of blood clots . Factor V is created in the liver .
What can Factor V Cause?
Factor V that becomes afflicted can cause numerous issues with the health of the human rakehell . The two most common hematological disease the handicap of Factor V causal agency are Factor V want or Owren ’s disease , and Factor V Leiden . Factor V Leiden is also have intercourse under its other name Factor V Leiden Thrombophilia .
Factor V Deficiency Vs. Factor V Leiden
Factor V Deficiency and Factor V Leiden are two entirely unlike sickness . Factor V Leiden is also called Factor V Leiden Thrombophillia . Unlike Factor V Deficiency Disorder , Factor V Leiden can only be inherit , not acquired .
Also , Factor V Deficiency do a individual who suffer from it would scantily be able to get the line clotted . On the other bridge player , the multitude who tolerate from Factor V Leiden have an increased blood clotting , which is know as hypercoagulabilty . Population that has Factor V Leiden is at a very in high spirits risk of develop giant and unnatural pedigree clots that can lead to cam stroke or tenderness flack . Factor V Deficiency can occur in the people of any race and/or gender . However , on the other hand , Factor V Leiden is almost entirely a disease of the European population . Almost 30 % of people that were diagnose with Pulmonary Embolism will also be diagnosed with Factor V Leiden .
Causes of Factor V Deficiency or Owren’s Disease
As it was said before , constituent V insufficiency or Owren ’s disease is an extremely rare haematological disease . This disease is either inherit from both of the parent in an autosomal recessive fashion or evolve by a person after its birth . Acquired Factor V deficiency or Owren ’s disease is because of either by an underlying aesculapian stipulation , sure medical drug , or by an autoimmune reaction .
Medical weather that might be a land for the development of acquired Factor quintet lack or Owren ’s disease are the chase :
People who were treated with certain types of fibrin gum can also get this disorder . At rare illustration , the cause of Factor vanadium want or Owren ’s disease is unknown . This haematological illness resemble Hemophilia . However , mortal who have Factor quintuplet deficiency or Owren ’s disease do not hemorrhage into their joints , as it is the case with the masses that suffer fromHemophilia .
Symptoms of Factor V Deficiency or Owren’s Disease
The symptom of Factor atomic number 23 deficiency or Owren ’s disease are ordinarily very mild . The level of Factor V can drop to only 20 % percentage in the line and still do not cause any serious job with the coagulation of pedigree . However , that stratum of Factor V in the blood will make the blood clot a little bit slower .
There are also symptoms of severe Factor pentad deficiency or Owren ’s disease that include :
Factor V Deficiency and Pregnancy
A pregnant female parent that have from Factor V deficiency or Owren ’s disease unremarkably does not have any problems during pregnancy . However , the mother that has Factor V inadequacy or Owren ’s disease can pass it on her child if the father of her tiddler also has this disease .
After give a nascence to her baby , a womanhood with this disease sometimes have severe and unnatural bleeding that have to be put under control by aesculapian professionals such as hematologists andgynecologists .
Factor V Deficiency and Anesthesia
People who have austere component V deficiency or Owren ’s disease and are scheduled to undergo a surgery must be aware of the fact that they could lose a lot of their rake , which could be life - threatening . However , since anaesthetist will be introduce to the fact that you have this condition , they will order donated blood for you in case start losing stemma sternly .
Tests to Diagnose Factor V Deficiency or Owren’s Disease
If your hematologist suspects that you might have this disorder , he / she will tell you to have a few tests . The diagnosis of Factor V want or Owren ’s disease is made through tests such as activated fond thrombokinase sentence ( aPTT ) test , thrombin clotting time ( TCT ) test , and prothrombin time ( PT ) test .
The final diagnosis of Factor 5 deficiency or Owren ’s disease is made through Factor V Assay .
Treatment for Factor V Deficiency or Owren’s Disease
Once a soul is diagnosed with knockout Factor fin deficiency or Owren ’s disease , it must start with a treatment right away . People that have mild form of Factor V deficiency or Owren ’s disease usually necessitate precautionary treatment .
The common treatment options for this illness are desmopressin , anasal spraygiven to a individual before surgery and dental function , then fresh frozen blood blood plasma or fresh blood plasma .
Home Remedies for Factor V Deficiency or Owren’s Disease
Homemade cooking that is abundant in blood - make solid food is the best household remedy for handle Factor V insufficiency or Owren ’s disease .
Diet for Factor V Deficiency or Owren’s Disease
Persons that brook from Factor V deficiency or Owren ’s disease are give notice to observe diet plans plentiful with food that build blood . That food let in the pursual :
Prevention of Factor V Deficiency or Owren’s Disease
lamentably , there is no particular way one can prevent getting this illness . fortuitously , Factor vanadium deficiency or Owren ’s disease is an extremely rare disease .
Risk Factors for Factor V Deficiency or Owren’s Disease
The biggest risk broker of bring Factor V insufficiency or Owren ’s disease is the transmitted factor . Children whose both parent were diagnosed in the past with Factor V want or Owren ’s disease are at the higher danger of set out this hematological disease since it is transmitted from a female parent to a child in an autosomal recessive fashion .
masses who have sure autoimmune diseases , such as lupus , are also at a risk of infection of developing Factor V want or Owren ’s disease . Several cancers can also induce the development of Factor quintuplet lack or Owren ’s disease . Women who had hard vaginal birth , in which they had lost a lot of blood are also at a risk of bring forth this hematological illness . Persons who have a family history of hemophilia can also build up agent V deficiency or Owren ’s disease .
Complications of Factor V Deficiency or Owren’s Disease
If an rudimentary Factor V lack or Owren ’s disease is not plow , it can get various knottiness . The most serious complications of Factor V lack or Owren ’s disease that could lead to death are stroke and heart flack .
One other serious knottiness of Factor V deficiency or Owren ’s disease is hemorrhage or unreasonable bleeding both inside and outside the dead body .
Prognosis/Outlook for Factor V Deficiency or Owren’s Disease
The overall medical prognosis for Factor V deficiency or Owren ’s disease is good if discussion for that disease is incorporated in time .
Lifestyle Changes for Factor V Deficiency or Owren’s Disease
No special lifestyle change have to be made by mass who stomach from Factor V deficiency or Owren ’s disease . This hoi polloi only have to eat foods that build blood and to avoid chance event , in which they could lose a lot of blood .
Coping with Factor V Deficiency or Owren’s Disease
People have a hard fourth dimension whenever they hear they have a certain illness . This also applies to the mass with Factor V deficiency or Owren ’s disease . The best way to make do with this disease is to lecture about it with kinfolk and friend .
There are also organization present all around the world such as American National Hemophilia Foundation where you could hang out with other people who suffer from Factor V want or Owren ’s disease and share your experience with the illness .
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