Pulmonary high blood pressure is a pathological experimental condition in which the ancestry pressure within the pulmonary arteries increase . The patient with pulmonic high blood pressure present withshortness of breath , dyspnea , tiredness , edema of lower limbs , chest pain , sometimes syncope . Pulmonary high blood pressure is bit by bit take place diseases affect old age group between 25 to 60 age more commonly .
The precise causa of Pulmonary high blood pressure ( PH ) is still unidentified but there are several hazard factor associated with the disease like COPD , Sickle cubicle anaemia , pneumonic embolism , disease of right Atrium , mitral valve stenosis . The Mechanism of Pulmonary Hypertension is opine to be due to inflammation of the lung artery .
Pathogenesis of Pulmonary Hypertension
Pulmonary Hypertension is multifactorial in Origin . It is often associate with cardiac and pulmonary abnormality . WHO has classified pulmonary hypertension on the basis of its causes into basal and secondary PH . principal high blood pressure is cause due to disease of the pneumonic arteries while secondary pulmonic hypertension is resulted due to other non - vascular causes .
Classification of Pulmonary Hypertension
WHO group 1- Pulmonary arterial hypertension :
It is caused due to-
WHO Group 1′- Pulmonary veno - occlusive diseases
WHO Group 1″- lasting pneumonic hypertension of newborn .
WHO Group 2- Pulmonary Hypertension developing secondary to leave behind kernel disease .
WHO Group 3- Pulmonary hypertension due to Pathology in the lungs :
WHO Group 4- Chronic arterial obstruction :
WHO Group 5- Pulmonary Hypertension with multifactorial chemical mechanism :
In the pathogenesis of pulmonary arterial Hypertension there is narrowing of the lumen of arteria going in and out of the lung parenchyma . This results in increased work load on the heart as heart has to pump the same amount of blood through the narrowed lumen . With the course of disease the wall of these arteries becomes hard and stiffer and stocky by the process of fibrosis . constrict of the lm of these artery is reckon to be due to cumulative issue of processes like vasoconstriction , remodeling of vessels ( due to fibrosis , incitive mediators ) . With the musical passage of time , the artery become stiffer and thicker due to vascular remodeling . This increases the origin pressure within the pulmonic vessels . This causes increase press on the right side of tenderness . Initially the correct side of heart attempt to repair these changes by hypertrophy and increase power of muscular contraction , but these changes fail to cope with the demand and the need of oxygen to the right atrial musculature down not met . So right side philia loser hap .
Pulmonary Hypertension due to left heart disease is not due to constriction or endothelial impairment to pulmonic vas . It is due to failure of the pumping activity of the right-hand side of nerve which causes the pooling of blood in the pulmonary vessel and back pressure in the pulmonic circulative organization .
In Pulmonary Hypertension of lung , hypoxia due to low tier of atomic number 8 to the pulmonic vessels there is happening of vasoconstriction of the pulmonic vessels . When the hypoxia is extensive and involving a much large area of the lung parenchyma , there happen a far-flung vasoconstriction of the Pulmonary vascular bed pass to increased pulmonary arterial pressure and substantiate high insistence in these vessels cause thickener of the musculature of the same result in free burning pulmonary Hypertension .
Conclusion
increase arterial pressure in the Pulmonary vascular bed is bear on to as Pulmonary Hypertension . In Pulmonary Hypertension there is morbid narrowing and/or rigidification of the pulmonic arterioles or capillaries this causes restrictive stream of blood line in arteries and results in increased pulmonic atmospheric pressure . Long condition Pulmonary Hypertension may lead to a right sided heart failure .
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