Various disease hap due to the familial mutant such as Down ’s syndrome and cystic fibrosis . Lynch syndrome is one such disease occurring due to the mutation in DNA mismatch repair genes . The symptoms of this syndrome are neither fatal nor non - achievable , but the important risk related to this disease is development of cancer . With proper charge and test , the risk can be cut down .
Is Lynch Syndrome An Autoimmune Disease?
Lynch syndrome is caused due to the familial mutation in the desoxyribonucleic acid repairing genes . The person affected with this mutation has the compromise power to correct the error in DNA . This lead to increase in risk of various Cancer such as colorectal Crab , endometrial cancer and stomach cancer . Autoimmune disease is the experimental condition wherein the resistant system of the body starts attack its own organs leave to morphologic and physiologic disfunction of the organ . Some examples of autoimmune disease arerheumatoid arthritis , Systemic Lupus ErythematosusandMultiple Sclerosis . Although it has certain characteristics of theCrohn ’s disease , which is an autoimmune disease , such as excessive production of mucin and signet electric cell feature , but the canonic pathophysiology is quite dissimilar in both the disease . There are studies that advise that the mutation in the defects in deoxyribonucleic acid mismatch repair genes may lead to autoimmune disease as the resistant arrangement does not sufficiently eliminate the ego - reactive triiodothyronine cell . However , the Lynch syndrome does not itself is an autoimmune disease nor it contributes to the developing of autoimmune disease .
Lynch Syndrome Causes
Lynch syndrome is caused due to the genetic sport in the desoxyribonucleic acid mismatch resort factor . The factor involve in Lynch syndrome are MLH1 , MSH2 , MSH6 and PMS2 . EPCAM cistron is sometimes involved in the Lynch syndrome . The mutation in a particular factor determines the increase in risk of build up cancer and its prospect . The risk of various cancer such as colorectal genus Cancer , hepatic cancer , urinary tract cancer and venter Cancer the Crab depends upon the gene in which chromosomal mutation has been come . Further , the female is also at risk of ovarian cancer and endometrial cancer due to Lynch syndrome . It has been found that men are more prostrate to colorectal Crab as compared to female person .
genetic mutation in gene MLH1 , and MSH2 causes greater risk of contracting cancer as compared to mutation in other gene . The increase risk of colorectal genus Cancer due to Lynch syndrome is as high as 70 % . Lynch syndrome is not enunciate to an autoimmune disease as the immune system is not involved in the disease rather it is genetic disease involving mutant of various genes . It has to be noted that Lynch syndrome does not fundamentally make cancer but increase the endangerment of cancer . Although no prophylactic handling is useable which can prevent the occurrence of this disease but there are sure measure which can be implement so as to reduce the risk of advance of lynch syndrome to Crab . These measures admit occasional screening and examination , surgical intervention , and changes in modus vivendi and the dieting .
Lynch Syndrome Symptoms
If the patient experience any of the above symptom , healthcare professional should be consult as soon as possible .
Conclusion
The autoimmune disease takes place when the immune scheme of the consistence lose its capacity to differentiate between the foreign tissue and the body ’s own tissue and attack on the national organs . The pathophysiology of the Lynch syndrome is unlike in the mode that Lynch syndrome is a genetic syndrome and occurs due to factor sport . Thus , it can be concluded that Lynch syndrome is not an autoimmune disease .
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