What is Lissencephaly?
Lissencephaly is a genetic disorderliness of the brain in which the brain does not develop the crease and vallecula that is needed for normal performance of the brain . Lissencephaly is an highly rare condition and affects the mental evolution of the youngster to a significant level .
Lissencephaly has been classified into three types which are type I , II , and III of which type I is the most severe and type III is the mildest form of Lissencephaly .
Anatomically speaking , the brain has a number of folds and grooves which are postulate to admit the numerous sum of mastermind tissues in a closed space . In cases of Lissencephaly , these grooves and sheepfold are missing and the brain is completely smooth resulting in unfitting performance of the encephalon have neural and developmental defects in a child .
This rifling and protein folding of the head start during fetal development . Abnormal factor are thought to be the main cause of Lissencephaly , although sure viral infection during gestation and poor origin blow to the fetus may also get this condition . The intervention for Lissencephaly is principally supportive and there is no cleared cut cure for this condition .
What are the Causes of Lissencephaly?
As state , Lissencephaly is a genetic condition and work have key several gene miscreation that may add to development of Lissencephaly . Additionally , sure viral infections and poor lineage flow to the fetus is also one of the effort for Lissencephaly .
Lissencephaly develops when the fetus is about 14 weeks erstwhile . It is in this phase of fetal evolution that the spunk cells commence to move to other field of the brain as they develop but in cases of Lissencephaly these nerve cubicle do not move resulting in the brainpower abnormality . Certain inherited aesculapian condition like Walker - Warburg syndrome have also been affiliate with Lissencephaly .
What are the Symptoms of Lissencephaly?
A baby carry with Lissencephaly may have an extremely minor head but this is not so in all the case of Lissencephaly . Some of the other symptoms of Lissencephaly are :
How is Lissencephaly Diagnosed?
In case if there is a family history of Lissencephaly in any of the parent then they can go for an ultrasound examination at about 20 weeks of pregnancy to check whether the fetus has Lissencephaly or not . aside from this , for confirmatively name Lissencephaly , the treat physician after respect the symptom may recommend advanced imaging of the brain in the form ofCTorMRI scansto looking for areas where folding has not take berth of the brain and reassert the diagnosing and degree of inclemency of Lissencephaly . Majority of child digest from class III which is the meek form of Lissencephaly .
How is Lissencephaly Treated?
There is no cure for Lissencephaly and the discourse aims at cater financial backing and ease to the child . Children who have problems with feeding and have difficulty swallow food may need an NG tubing placed for nutritional purposes .
In cases where a child has hydrocephalus due to Lissencephaly then operating room may be required to run out the excess fluid accumulated in the brain . Medications will be command to control seizures as a result of Lissencephaly .
What is the Prognosis of Lissencephaly?
The overall prognosis of Lissencephaly look on the severity of the condition . A small fry suffering from grade I Lissencephaly which is the most wicked form will have an extremely poor forecast for functioning normally and may not develop beyond a three month storey in term of function . Children with mild chassis of Lissencephaly tend to more or less lead a normal modus vivendi with very little if any brain abnormalities due to Lissencephaly .
