What Is Ménétrier’s Disease?
Ménétrier ’s Disease is a pathological shape in which there is magnification of rugae , which are ridge present along the inside part of the wall of the stomach resulting in organisation of large folds within the lining of the stomach . This magnification of rugae takes place usually due to overgrowth of mucose cells in the wall of the stomach . Under normal circumstance , the mucous cellphone present in the rugae departure mucous secretion own proteins . In cases of exaggerated rugae , the mucous cells make excessive proteins which are then leaked from the blood stream into the stomach causing the blood to become deficient of protein result in a condition hypoproteinemia . This disease also reduces superman - create cells in the tummy ensue in decreased yield of breadbasket acid .
What Are The Causes Of Ménétrier’s Disease?
researcher are still not quite sure about the accurate cause of Ménétrier ’s Disease , although they are of the opinion that this disease is an acquire one rather than an inherited one , although there have been extremely rare case in which siblings have work on to originate this consideration suggesting that there may be a genetic tie-in to Ménétrier ’s Disease . Studies bespeak that individuals with Ménétrier ’s Disease have excessive sum of protein called transform growth factor - alpha , the overrun of which causes Ménétrier ’s Disease . Studies also show sealed case in which Ménétrier ’s Disease was find in people who have had H. Pylori infection and treatment for H. Pylori have improved the symptoms because of Ménétrier ’s Disease . Researchers have also found sure sheath in which CMV has been tie with development of Ménétrier ’s Disease , although they are still not quite certain as to how H. Pylori and CMV are tie to the development of Ménétrier ’s Disease .
What Are The Symptoms Of Ménétrier’s Disease?
Some of the symptom of Ménétrier ’s Disease are :
How Is Ménétrier’s Disease Diagnosed?
The diagnosis of Ménétrier ’s Disease is made by a combining of history and strong-arm examen , lab examination , and upper GI endoscopy along with a biopsy of the stomach tissues . To start with , the treating physician will take a elaborate history and conduct a forcible examen . The next step in reassert the diagnosis will be to lead a CT CAT scan which will easily show magnified plica in the facing of the stomach thus corroborate the disease along with doing an upper Gb endoscopy . Tests may also be done to look for bearing of H. Pylori or cytomegalovirus . A biopsy of the belly tissue paper will also be taken and analyzed looking for any changes in the mucous cells of the breadbasket .
What Are The Treatments For Ménétrier’s Disease?
intervention for Ménétrier ’s Disease include medications , extract of protein intravenously , blood transfusion , and even surgery .
medicinal drug : The physician may prescribe anticancer medicament like cetuximab for treatment of Ménétrier ’s disease . Studies indicate that this medicament is useful in reducing the thickness of the breadbasket wall and also improve the patient ’s symptom significantly . This medicine is give intravenously , although studies to investigate the efficacy of this medication are still on-going . Apart from this , the treating doctor may also prescribe medications for restraint of sickness and abdominal painfulness due to Ménétrier ’s Disease . In cases where Ménétrier ’s Disease is caused due to H. Pylori or CMV , regale these above circumstance go a prospicient way in meliorate symptoms .
endovenous extract of Protein and Blood transfusion : This treatment is done in person who become super malnourished or anemic due to Ménétrier ’s Disease .
Surgery : In cases of severe Ménétrier ’s Disease , surgical operation may be required to get rid of a part of all of the breadbasket . This procedure is yell gastrectomy . Postprocedure , the surgeon will reconstruct the portion of the gastrointestinal nerve pathway . Usually , the surgeon will fall in the small intestine to the part of stomach that is still left .
