Madelung Disease is one of the seldom fall out health conditions when increase oflipomasor fatty tumors takes place around the upper torso , upper implements of war , shoulders and neck . These look very odd and the affected soul gets unpredictable shape in those constituent of the body which capture contiguous attention of outsider and induce peripheral neuropathy . Madelung Disease is also known as multiple symmetriclipomatosis , benign symmetrical lipomatosis , and Launois - Bensaude .
German surgeon , Otto Wilhelm Madelung name this disease and its symptom in detail for the first sentence and since then the disease is mostly called ‘ Madelung Disease ’ . Although enquiry suggests a strong connection betweenalcoholconsumption and Madelung disease or benignant symmetrical lipomatosis , yet , in some situation , it is found that non - souse are also affected by Madelung disease . The signs and symptoms of Madelung disease or benignant symmetric lipomatosis vary from mortal to person . If not treated in time , the fatty tissues pile up chop-chop hampering the normal mobility of the neck or the other touched body parts . meek to grave pains may develop disturbing the normal activities of the affected citizenry . The lipomas do n’t become cancerous commonly , but may be link up with mutation in mitochondrial DNA .
Symptoms of Madelung Disease or Benign Symmetric Lipomatosis
The signs and symptom of Madelung disease or benign symmetric lipomatosis alter from one person to another . It is characterize by the symmetrical growth of fat tumors around the neck , berm , upper arms and upper torso . Again , these fat growth may be fast in some persons and very slow in others . In most of the causa the lipomas are benign , but may get pain if former treatment is not set forth .
multiple of symptom are assort with Madelung disease or benign symmetrical lipomatosis . Some of these are as keep abreast –
patient with Madelung disease or benignant symmetric lipomatosis may sometimes also develop peripheral neuropathy including other neurologic disturbances like difficultness in swallowing , slumber problems , hoarseness , hypertension , temporary breathing and increment in heart rate . In advanced stagecoach , it may lead to liver issues as well ashypothyroidism .
Epidemiology of Madelung Disease or Benign Symmetric Lipomatosis
As per the statistic , people between the ages of 30 to 70 years with a history of Mediterranean ancestry are establish to be vulnerable to benign symmetrical lipomatosis . People with higher proneness of intoxicant intake are also at higher peril of ingest this uncommon disease . The disease is not much visible , 1 in 25000 people have been detected with some symptoms of Madelung disease or benign symmetrical lipomatosis . Moreover , males are more affected by Madelung disease than females with a ratio of 30:1 .
Prognosis of Madelung Disease or Benign Symmetric Lipomatosis
In 60 % of cases , there have been notice recurrences of Madelung disease or benign symmetric lipomatosis lead to further surgeries or suction lipectomy . However , peril of recurrence of Madelung disease or benign symmetric lipomatosis reduces drastically when treatment procedure and behavioural change are followed rigorously .
Causes of Madelung Disease or Benign Symmetric Lipomatosis
The exact basic causa of Madelung disease or benignant symmetric lipomatosis is not clear to the researcher till now . However , at different stage of time several theories have been nominate by the research worker which are as follow :
Risk Factors of Madelung Disease or Benign Symmetric Lipomatosis
It is hard to name up all the risk cistron , since research worker are yet to collect sufficient grounds against all the risk factors of this rarified disease . However , people predisposed to alcohol abuse and make story of Madelung disease in class are at higher risk of exposure of getting affected by Benign Symmetric Lipomatosis .
Complications Related to Madelung Disease or Benign Symmetric Lipomatosis
In extremely rarefied shape , lipomas in Madelung Disease or benignant symmetrical lipomatosis may become malignant . A few case of head and neck opening cancers are detected with Madelung Disease ; however , investigator are yet to affiliate any precise link of Madelung disease or benign symmetric lipomatosis with cancer . The dying charge per unit of 10 % in pillow slip of detain diagnosis is established and in this shell patient role have died of asphyxiation . Thus , except return of lipomas no other serious complications are usually find in Madelung Disease or Benign Symmetric Lipomatosis .
Diagnosis of Madelung Disease or Benign Symmetric Lipomatosis
CT scan and MRI are used to detect Madelung Disease or benignant symmetric lipomatosis ; however experts also take lifestyle and family history of the patient before name madelung disease or benign symmetric lipomatosis . In some typeface , doctors also ask for biopsies of the adipose tumor to sustain the disease .
Treatment of Madelung Disease or Benign Symmetric Lipomatosis
In most of the cases , lipoma are surgically operated , but in recent times suction lipectomy is mostly used to murder the lipoma quickly and in effect . Liposuction method is technically perfect and requires minimum incision ; hence , this method go forth belittled scars in the operate on country . Moreover , liposuction has no risk and side - effects , which is gentle to dramatise and patients recover faster than normal operative method . However , in some vital situations like presence of large deposit of fat with superficial hardness , and/or lipomas with airway compressions etc . , are times where traditional surgery becomes inevitable .
operative excision extirpate the lipomas more effectively , but it is not always possible to remove the lipomas altogether through operative process and liposuction . As a result , there stay on a bully possibility of recurrence of same symptom if proper treatment subroutine is not followed and along with lifestyle change .
medication like salbutamol serve to breakdown the fatty acids in the body , thus many Dr. apply it consequently . At the same time , abstaining from alcoholic drink , get potent regime for weight loss and treatment for endocrine irregularity are required to prevent further ontogeny of lipomas .
Madelung disease or benignant symmetric lipomatosis is categorized as a rare one when mostly benign lipomas are developed in certain parts of the body . Much of the disease and its causes are still not clear to the researchers , but a few risk factors like drunkenness and family history are found to be closely colligate with the disease . The adipose tumor count very odd ; hence , doctors notify for the earliest potential liposuctions or surgeries , look on the severity of each case . A certain modus vivendi change and some medications are needed even after the surgery , to prevent recurrence of the disease .
