Pulmonary veno - occlusive disease is a very rarefied stipulation in which pulmonary hypertension use up place . This lead to obstruct blood flow within the small-scale pneumonic vein thereby cause gamy origin pressure in the pulmonary arterial blood vessel . Pulmonary veno - occlusive disease is reformist and life menace .
What is Pulmonary Veno-occlusive Disease?
Veno - occlusive diseases or VOD occur when the veins get congested lead to obstruction and tissue necrosis . This more and more moderate to failure of the organ of the affected region or subsequent death . Veno - occlusive diseases or VOD is classify into two category hepatic veno - occlusive disease and pulmonary veno - occlusive disease . In case of hepatic Veno - occlusive disease , the portal venous blood vessel associated with liver undergo portal hypertension ; whereas in case of pulmonary veno - occlusive disease , the pneumonic venous blood vessel get foul and suffer from pulmonary hypertension .
Pulmonary veno - occlusive disease is characterized by the occurrent of fibrosis within the small pulmonic veins and capillary tube , leading to accumulation of the pulmonary interstitial fluid . This further increase the pulmonary vascular underground and occurrence of pulmonary edema . The pulmonic arteria which are straight off connected to the good heart ventricle have in high spirits pressure sensation built in due to the increase in pneumonic vascular electrical resistance which lead to impairment of the right ventricle . With progression of age , the condition gets worse accompanied by constringe pulmonary nervure with congestion , swell of lungs and pulmonic artery high blood pressure .
Symptoms of Pulmonary Veno-occlusive Disease
vernacular symptom that endure due to pulmonic veno - occlusive disease are :
Epidemiology of Pulmonary Veno-occlusive Disease
The incidence pace for Pulmonary Veno - occlusive Disease is one in five million with around ten percent shell suffering from pulmonary arterial blood vessel high blood pressure and around twenty pct cases grow due to hereditary factors .
Prognosis of Pulmonary Veno-occlusive Disease
The prognosis or prospect for pulmonic veno - occlusive disease is very poor with most patient dying within two year of diagnosis . In instance of infants the survival is only up to a few weeks .
Causes of Pulmonary Veno-occlusive Disease
The principal get that contribute to pulmonary veno - occlusive disease or VOD are :
Pathophysiology of Pulmonary Veno-occlusive Disease
The prime mechanics of the wound to the pulmonary sine curve is due to muscle contraction and obstruction of the pneumonic vein and capillary vein . The onset of this occlusion and constriction begins with accumulation of fluid within the pulmonary tissues which progressively become thick and obtuse sclerotic fibrous tissue . In gain to this , these tissues take shape an intimal thickening on the walls of the veins and venules which do narrowing of the pneumonic veins , but this never pass off in the large veins . aside from bottleneck of the pulmonary vein , dilation of the lymphatic capillary also occurs which contributes to pulmonary veno - occlusive disease .
Risk Factors of Pulmonary Veno-occlusive Disease
The major danger component that pose a terror of pulmonary veno - occlusive disease are :
Complications of Pulmonary Veno-occlusive Disease
The possible complications of pulmonic veno - occlusive disease are :
Diagnosis of Pulmonary Veno-occlusive Disease
Pulmonary veno - occlusive disease can be diagnosed through below procedures :
Treatment of Pulmonary Veno-occlusive Disease
There are sure treatments available to treat pneumonic veno - occlusive disease as well as it ’s up surge complications but the effects of them are not up to the ask levels . Some such handling are :
Pulmonary veno - occlusive upset is a condition about which not much is known . It is a status that go up due to several vital factors which cause blockage of the pulmonic nervure . The condition is ordinarily misdiagnosed or diagnosed at a later degree . This lead to high deathrate charge per unit amongst the patients . The only handling that promises a keep up life story to the patient is the lung transplantation but that too is shadowed by the recollective wait time for the pipe organ contribution .
