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Kidney is a critical organ in our body and since its affair is to remove dissipation ware from our body it becomes an extremely significant part of our body . Various disease cause kidney price resulting in malfunction ofkidney . Kidney malfunction causes progressive buildup of barren Cartesian product in our physical structure resulting in various , potentially serious , medical complication . One such aesculapian condition which affects the kidneys is Renal Amyloidosis . In this article , we will discuss about the various causes , symptom , and treatments deliver for Renal Amyloidosis .
How Is Renal Amyloidosis Defined?
Amyloidosis is a medical disorder which is caused due to deposition of extracellular or intracellular amyloid strand alter normal mapping of tissues . When there is dethronement of amyloid fibril in the kidney , it is then call as Renal Amyloidosis .
Causes Of Renal Amyloidosis
The possible cause of the production of amyloid and the reason for its deposition in tissues is soon not known . likely factors are varied allot to the subtype of amyloid .
Literature though evoke amyloidosis is heriditory disease.1Renal amyloidosis associate with the R554L AFib variant has been note in few phratry studies.1
Some studies suggest renal amyloidosis follows nephritic coronary artery disease of arterial rakehell vas .
Risk Factors For Renal Amyloidosis
The major hazard factor for evolution of Renal Amyloidosis is a family story of neuromuscular disease of unknown etiology.2
Classifications Of Amyloidosis
Symptoms Of Renal Amyloidosis
Some Of The Symptoms Of Renal Amyloidosis Are:
Diagnosis of Renal Amyloidosis
If an individual experiences the above mentioned symptoms and Renal Amyloidosis is suspected , then the Dr. may order a renal biopsy to confirm the diagnosis of Renal Amyloidosis . asunder from the nephritic biopsy , the following tests can also be ordered .
Treatment For Renal Amyloidosis
As of now , no treatment is available to specifically target amyloid depositions ; thus , therapy is targeted towards preserving the organ function.4
In gild to regale renal loser , diuretic can be used and erythropoietin is pay to do by genus Anemia . Treatment of underlying causes result in this condition like instigative circumstance or carcinoma is of import .
High dose of corticosteroids has been assay in the past with temperate success.3
Liver transplantation has also demo to be effective in some subtypes of Amyloidosis ; however , even then disease progression is observe . For Renal Amyloidosis , Kidney transplant is done .
Prognosis Of Renal Amyloidosis
The prognosis for Renal Amyloidosis is unfortunately not good and people with this condition usually tend to deteriorate and end up with complications which are potentially terminal . In such cases , treatment is basically focused on comfort care and relievo of pain .
References
1 . patrimonial amyloidosis make by R554L fibrinogen Aα - chain mutation in a Spanish family and recap of the literature .
Haidinger M1 , Werzowa J , Kain R , Antlanger M , Hecking M , Pfaffenberger S , Mascherbauer J , Gremmel T , Gilbertson JA , Rowczenio D , Weichhart T , Kopecky C , Hörl WH , Hawkins PN , Säemann MD .
Med Ann Dist Columbia . 1967 Apr;36(4):228 - 31 passim .
2 . Amyloidosis : review of cardiac and renal manifestations .
Barth WF . , Amyloid . 2013 Jun;20(2):72 - 9 .
3 . Update on discourse of light chain amyloidosis .
Mahmood S1 , Palladini G , Sanchorawala V , Wechalekar A.
Haematologica . 2014 Feb;99(2):209 - 21 .
4 . Amyloidosis - assort kidney disease .
Dember LM .
J Am Soc Nephrol . 2006 Dec;17(12):3458 - 71 .
