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Salsalate is separate as Non - steroidal anti - rabble-rousing drug ( NSAIDs ) in Salicylate group . Salsalate apace absorbed in intestine and also speedily obviate in 3.5 to6 6 hour . The maximal therapeutic effect is observe only after 3 to 4 day . Salicylates are COX 1 inhibitors and anti - inflammatory medicine . Three medication Empirin , Diflunisal and Salsalate are classified under salicylates group . Aspirin is most often used as an anti - inflammatory medicinal drug to prevent blocking of coronary arteria inmate suffering with coronary artery disease as well as address pain and pyrexia . Salsalate do less of a gastric side effects resulting in gastropathy than naproxen .
Alternative Name of Salsalate
Salsalate is also known as Disalcid , Salsitab , and Salflex
Mechanism of Action of Salsalate
Salsalate is a weak Cox inhibitor of prostaglandin . The medication also fall secretion of interleukin-6 and TNF - alpha that is found in inflammatory tissue . Salsalate also conquer IkB kinase enzyme which set off the secernment of prostaglandin and coulomb reactive protein . The inhibition of IkB kinase enzyme helps to sensitise insulin receptors resulting in decrease level of blood sugar when insulin is dynamic at the receptors . Salsalate separate into two particle following absorption in intestine .
Pain- Salsalate is used for acute and chronic pain in the neck . Most acute nociceptive pain react to salsalate . inveterate neuropathic pain often do not response to salsalate lozenge .
Fever- Fever is treated with salsalate if not responding to aspirin . Salsalate dosage required to reduce fever may be higher than analgetic dose .
Inflammation- The tissue paper and joint inflammation responds to salsalate treatment . The pain saturation is also decreased if the spread of inflammation is decoct .
Dosage of Salsalate
Salsalate is sold on shelf . The medication is uncommitted as pills and capsule . The enduringness of pills are 500 mg and 750 mg pad . Pills are given 2 to 4 meter a solar day depend on reply of infliction relief . Maximum dose suffer by adult is 3,000 magnesium .
Duration of Action
The pain relievo is experienced 2 to 3 hours after the consumption of pills . The bother relief endure 3 to 6 hour survey initial dosage . The maximal dosage used in children is 30 mg / kgm .
Side Effects Caused by Salsalate
References-
appraisal of salsalate , a nonacetylated salicylate , in the treatment of patient with arthritis .
Atkinson MH1 , Ménard HA , Kalish GH . ,
Clin Ther . 1995 Sep - Oct;17(5):827 - 37 .
Reduced hazard of NSAID gastropathy ( GI mucosal perniciousness ) with nonacetylated salicylate ( salsalate ): an endoscopic bailiwick .
Roth S1 , Bennett R , Caldron P , Hartman R , Mitchell C , Doucette M , Ekholm B , Goldlust B , Lee E , Wilson R.
Semin Arthritis Rheum . 1990 Feb;19(4 Suppl 2):11 - 9 .
Potentiation of Warfarin Associated with Salsalate Therapy Resulting in Bleeding .
Rindone JP1 , Mellen CK1 . ,
Curr Drug Saf . 2018;13(2):141 - 143 . doi : 10.2174/1574886313666180219165742 .
