What is Systemic Mastocytosis?
Systemic Mastocytosis is a pathological condition characterize by unnatural collection of mast cell in the tissue paper of vital organs of the body like the liver , lien , ivory marrow , and small intestine .
Systemic Mastocytosis is normally seen in adults . The symptoms of Systemic Mastocytosis are varying and calculate on the organ that is affected by the shape . Systemic Mastocytosis is basically have by mutation of the KIT factor which is responsible for for various functions of the cells .
Majority of the case of Systemic Mastocytosis are not inherited but are get due to sporadic variation of the KIT gene even though some transmissible case have been reported of Systemic Mastocytosis . There are four main types of Systemic Mastocytosis . These are :
It is important for an individual who has been diagnosed with Systemic Mastocytosis to identify the type of the condition as the discussion and the overall medical prognosis are dissimilar for different type of Systemic Mastocytosis .
What are the Causes of Systemic Mastocytosis?
As stated , the solution cause for Systemic Mastocytosis is mutation in the KIT cistron . This chromosomal mutation is in most instance sporadic and does not follow any inheritance shape . The subroutine of the gene is to produce a protein responsible for various cellular process and cellular phone growth and division .
This protein is also creditworthy for development of mast cellular phone which are resistant electric cell which are necessary for inflammatory response by the body . The abnormal chromosomal mutation of the KIT cistron results in overrun of the mast cells which then start to hoard in the tissue of the various organ of the body leading to the symptom of Systemic Mastocytosis .
What are the Symptoms of Systemic Mastocytosis?
The symptoms of Systemic Mastocytosis calculate on which part of the body is affected by the mast cells , whether it is intestine , liver , spleen , or the bone pith . Some of the symptoms which are common irrespective of the affected pipe organ are :
How is Systemic Mastocytosis Diagnosed?
Systemic Mastocytosis is suspected based on the symptoms that the affected role represent with . Various investigational studies may be done to rule out other conditions that may be causing similar symptom .
Once all these condition are reign out then a confirmatory diagnosis is made of Systemic Mastocytosis . Some of the tests done to name Systemic Mastocytosis are :
What is the Treatment for Systemic Mastocytosis?
The treatment for Systemic Mastocytosis depends on the symptoms of the patient and the type of Systemic Mastocytosis . Some of the medications that are used to handle Systemic Mastocytosis are antihistamine for skin and gastrointestinal symptoms , PPIs for increased acid in the stomach .
In cases of anaphylaxis due to tortuousness of Systemic Mastocytosis , epinephrine may be utilized . steroid hormone may be give to treat malabsorption . In typesetter’s case if the condition is malignant then steroid along with chemotherapy will be devote to do by Systemic Mastocytosis .
