Pericarditis is a human heart disorder in which the liner of the heart becomes inflamed . This lining is called the pericardium . The pericardium perform many authoritative roles that aid to the normal operation of the heart . It holds the human heart in its appropriate position in the chest ; it protects the heart from infection by separate it from the other intimate Hammond organ and prevents the heart from overfilling with profligate . It also lubricates the heart with the pericardial fluid to reduce the clash produced because of the contraction and liberalization of the heart muscles .
Pericarditis can be either incisive or chronic in nature . Acute pericarditis recrudesce abruptly and is typically resolved within three weeks with rest and therapy . The patient typically complain of a penetrative painful sensation the chest that resemble the pain experienced during aheart attack . This pain is say when the patient inhales and improves when the patient list forward while sitting up . The patients also experiences humiliated blood press , a high temperature ( febrility ) , and heart quivering . In chronic pericarditis , the symptoms develop bit by bit over a menstruation of many months . It also takes longer to handle the status and more often than not , the patient develops further complications .
What are the Existing Therapy Options And What Are Their Limitations?
Pericarditis can be handle with a salmagundi of medication . The end of intervention is to reduce the inflammation of the pericardium . In most clinical setting , this is usually achieve by bulge out the patient on anon - steroidal anti - instigative drug ( NSAID)such as ibuprofen or Empirin . If the patient does not reply toNSAIDs , corticosteroids are added to the discussion regimen . This is because corticosteroids are associated with a prompt reliever of symptoms .
However , recurrence of symptoms is a serious ramification associated acute pericarditis . This usually is seen within a few week of handling discontinuation . This incidence of return is noticeable higher in the patient role cover with corticosteroids . Some of the clinical studies have demonstrated that addition of corticosteroids to the discourse regime is really an autonomous risk broker for develop repeated pericarditis . Therefore , there is a want for a treatment option that will cover acute pericarditis and at the same prison term prevent the episodes of return .
What does Colchicine do for Pericarditis?
How does colchicine liken to other handling options ? Colchicine is an anti - inflammatory drug . primarily it binds to the microtubules in the nucleus of the cell to curb mitosis , disrupt polymorphonuclear cell function and interferes with the movement of collagen in cells .
Several detective have hit the books colchicine to appraise its effectivity in the clinical treatment of pericarditis . The results of these studies betoken that the usage of colchicine as an adjuvant treatment of acute pericarditis show considerable meritoriousness . The major benefit observed was that the patients treated with colchicine were associated with a lower relative incidence of recurrence . However , the mechanism by which colchicine kickshaw pericarditis is still not clear .
In one salient clinical study , patients with acute pericarditis were prescribe either only acetylsalicylic acid or a combination of colchicine and St. Joseph . The results of this study demonstrated that the patient role treated with colchicine had a decrease in their symptoms 72 hours after the first pericarditis episode . After about 18 months , these affected role were also seen to have a importantly low charge per unit of return ( lessen by two thirds ) . In addition , the use of colchicine was not associated with serious adverse effect and none of the patients evolve any continuing pericarditis complication like restricting pericarditis orcardiomyopathy . The only contrary event which top to patient discontinuation was diarrhea .
Thus , the use of colchicine in the treatment of pericarditis search hopeful . It is recommend that affected role live their first instalment of pericarditis should bulge out discourse with an NSAID like Bayer . If that is not effective , then colchicine should be prefer over other conventional corticosteroids . This will help in reduce the return rate of pericarditis .
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