Many drugs can affect the way the liver functions . The liver is the most interesting organ in the human being which performs a various function . One of the major functions of the liver is metabolism ; it processes a encompassing range of drug resulting in the water - soluble end merchandise which is excreted in the bile . There are numerous drug sold in the market which can bring a deleterious effect to the liver mathematical function . The prolonged use of the medicinal drug may increase the liver enzyme abnormally and can neuter the metabolic activity resulting in liver-colored failure . Jaundice , stomach discomfort , burning sensation , and trend to offend and phlebotomise are some of the symptom of drug perniciousness .
What Drugs Are Bad For The Liver?
Clinicians refer to this condition as “ drug - induced liver combat injury ” . The term also includes damage make by toxic herbaceous plant or plants and nutritional supplement .
Paracetamol is the most common conventional drug accept in overdose in the westerly commonwealth . It is toxic to the liver even at low share can induce hepatocellular gangrene which can result in fatal liver nonstarter . A 7.5 g of paracetamol can totally alter the pathway of metabolism .
Amoxicillin is a authoritative case of an antibiotic drug used for upper respiratory tract complaints such as bronchitis , sinus and pharynx infection . Liver scathe from amoxicillin can materialize soon after take it . The signs of liver injury are often detected even after withdrawal of the medicine .
Antibiotics such as clindamycin , erythromycin , nitrofurantoin , rifampin , sulfonamides , tetracyclines , trimethoprim / sulfamethoxazole , INH , and pyrazinamide can make liver damage if appropriate STD not followed . Isoniazid is a well - known anti - tuberculosis drug , which can get knifelike liver injury .
Anticonvulsant medications such as carbamazepine , phenobarbital , phenytoin , and valproate have been imply in cause idiosyncratic drug - stimulate liver disease .
Prolong use of statins can induce brawn pain , digestive problems , mental fogginess and may seldom get liver wrong . It is used as an anti - cholesterol drug , can increase the levels of liver enzymes and stimulate liver damage ordinarily venial but no symptoms .
Certain inhalational factor , primarily halothane , have been implicated in causing liver hepatitis . There are two type of halothane - hasten liver hepatitis . Type 1 which is mild , fugacious and has a relatively mellow incidence ( 25 to 30 % ) . eccentric 2 make by oxidative metabolism of halothane in the liver leading to fever , thorniness , and dramatically elevated blood serum transaminases .
nuisance relievers like non - steroidal anti - inflammatory drugs ( NSAIDs ) can also cause liver injury , model -diclofenac .
Several anti - seizure medicine such as dilantin , carbamazepine , and lamotrigine can cause liver damage . Carbamazepine and lamotrigine can induct make liver trauma in patients who have been take it for calendar week or months .
At present , anti - sedative drug are the most commonly prescribed drug and also significant cause of drug - bring on liver wound – Bupropion , fluoxetine hydrocholoride , mirtazapine , paroxetine , Zoloft , trazodone , and tricyclic antidepressants such as amitriptyline hydrochloride . Risperidone and quetiapine are both used as major tranquilliser and antidepressants . These medications can cause a blockage in the flow of gall from the liver .
Other drugs admit heart drug ( Cordarone and clopidogrel ) , cancer drug methotrexate sodium , and antiretroviral therapy drug ( used to care for HIV infection ) can make liver injury .
Medicinal Herbs-Induced Liver Damage
Some medicinal herbs hold toxic subject matter that can damage the liver . Herbs contain a high concentration of alkaloids can rush 20 % wrong to the liver . These admit dietary supplements with a high amount of pyrrolizidine alkaloids . This may be realize in some teatime extract , which cause abdominal pain and sometimes sick . liquid accumulates in the abdomen and pegleg and eventually , scar tissue paper in the liver , liver failure , and even destruction may leave . These herbs include Borago officinalis , pennyroyal vegetable oil , celandine ( in the poppy family ) , Kombucha tea , misteltoe , Sho - saiko - to , yerba afternoon tea , comfrey , and certain Taiwanese herbs , such as zi cao ( groomwell ) , kuan dong hua ( coltsfoot ) , qian li guang ( liferoot ) , and pei lan ( Eupatorium ) .
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