What Drugs can Cause Pericarditis?
Medication - induced pericardiac fervor is an uncommon condition . The precise progress of drug - induced pericarditis is obscure ( idiopathic pericarditis ) . Some of the drugs usually observed to induce this condition include isoniazid , cyclosporine , procainamide , dantrolene , doxorubicin , penicillin , Apresoline , Coumadin , and heparin . The continuing consumption of the drug may be the cause for getting this condition . The adverse reaction of the drug to the consistency is the risk divisor for pericarditis .
Interferon-based Drugs
Interferon - based drugs used for many purposes for treating various cancer and computer virus transmission . It has the same property which our body naturally synthetic thinking , but when used for a chronic condition , it induces several side effects . Some of the most vernacular side effects include flu - like illness , pectus hurting , alopecia , efflorescence , pancytopenia , myalgias , and hepatotoxicity . Interferon drug - mediate pericarditis is not well - defined , exceptionally infrequent and among the unlike synthetic thinking , interferon alpha is know to be the most cardiotoxic . It causes an autoimmune reaction through various mechanisms including production of gamma - globulins and interleukin-6 and prohibition of allospecific suppressor T lymphocyte , as well as activation of rude sea wolf cell .
Actinomycin - D , anthracyclines , bleomycin , bromocriptine , cisplatin unite with 5 - fluorouracil , cyclophosphamide , cytarabine , methysergide , minoxidil , morrhuate sodium , phenylbutazone , and tocainide have been link up with the ontogeny of pericarditis . Among these drugs , mesalamine and sulfasalazine - containing have unassailable potential in the cause of pericarditis . Pharma companies of oral and rectal mesalamine and sulfasalazine producers , list pericarditis as an rare contrary drug reaction in their information pamphlet . The underlying relationship between pericarditis and medicine with same pharmacologic natural action , such as olsalazine and balsalazide , is incertain . Methysergide drug is an ergot alkaloid used prophylactically for the treatment of a migraine and bunch headache . Patient has shown develop constrictive pericarditis while on foresightful - term methysergide therapy and now no longer used for first - line discourse .
In drug - induce systemic lupus erythematosus , chest pain is the major symptom induce by redness of the liner that wall the lung ( pleuritis ) and the heart ( pericarditis ) . Cardiac manifestations are in the main unusual in hydralazine - induced lupus . Pericarditis pass off less than 5 % in hydralazine - induced lupus as liken to 20 % in the spontaneously hap systemic lupus erythematosus . Recurrent pericardial ebullition cases were reported because of drug - induced systemic lupus erythematosus , which lead in mitral valve repair . Carbamazepine as an anti - convulsive drug has been identified to cause lupus disease in several cases .
The anti - coagulant drugs have a significant part in bring on the pericardiac effusion . Coumadin , heparin , and antithrombotic agent such as aspirin and dipyridamole have a role in persuading major pericardiac ebullition along with vascular complication , GI hemorrhage . Major pericardial effusion is define as cardiac tamponade with a degree of fluid > 10 millimetre which require immediate treatment such as pericardial puncture or surgical procedure . Minor pericardiac effusion is define as a level of fluid < 10 mm , which can be managed with drug discussion .
Signs and Symptoms of Medication-Induced Pericardial Inflammation
The signboard and symptom of medicament - induce pericardial inflammation admit immunoglobulin E - intermediate allergic reaction , direct cardiac perniciousness , humoral antibody answer , and cell - mediated hypersensitivity , and peripheral eosinophilia . difficultness breathing , which gets big specially while reclining or lying down , Swelling of the stage and invertebrate foot ( edema ) , low - grade pyrexia , chills , sweating , breast pain ; and pain in chest increases on coughing or swallowing . The severity of medication - induct pericardial inflammation may vary and it is hard to predict who catch mild or wicked symptoms .
The best therapy for drug - induced pericarditis postulate the prompt backdown of the risk link up with drug intake and discourse of its signs and symptom . If the condition is not treat on clock time , it may run to life - threaten symptoms . discourse with nonsteroidal anti - inflammatory drug and colchicine outcomes in dependable recovery additionally , diuretic help to minify excess fluid accumulation in the body may be administered
The best combining drugs are is ibuprofen and colchicine . Ibuprofen has several advantage , for instances , it gradually increases the coronary blood menses while the other drug has poor coronary blood flow . Indomethacin usually controls pain but has a inadequate adverse event profile and reduces coronary menses . The use of colchicine lean to prevent recurrent pericarditis .
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