What is Miller Fisher Syndrome?
Miller Fisher syndrome ( also jazz as Fisher ’s syndrome , Cranial discrepancy ofGuillain - Barré syndromeand Cranial variant of GBS ) is an acquired disease of the heart and is a uncommon disease . Miller Fisher syndrome is considered to be a stochastic variable of Guillain - Barré syndrome .
Why the Name Miller Fisher Syndrome?
Miller Fisher Syndrome is named after Dr. C. Miller Fisher who had first described this condition as a modified variant of Guillain - Barré syndrome ( GBS ) .
What Causes Miller Fisher Syndrome?
The exact cause of Miller Fisher Syndrome is not cleared . The waddling pace of the affected role is thought to occur as a result of loss of medulla around the nerve . There can also be involvement of other sensory fibre , autonomic and motor fibers which innervate the muscles which move the font and middle along with control the function of the middle , student and vesica . There is evidence of auto - immune mechanics where the triggering / predate transmission stimulates the production of an antibody which reacts to sugar found on both the surface of peripheral nerve and the infective being causing demyelination and loss of nerve occasion .
What are the Symptoms of Miller Fisher Syndrome?
The characteristic symptom of Miller Fisher syndrome is abnormal muscle coordination where the patient ’s walk becomes fumbling or slapdash ; absence of deep tendon reflex ( mortise joint jerk and knee joint jerked meat ) ; and palsy of the muscles of the eye where the affected role also experiences fuzzy ordouble visual modality , facial weakness anddroopy eyelids . As Miller Fisher syndrome is a variant of Guillain - Barré syndrome , the symptoms of Miller Fisher syndrome are also preceded by a viral malady just as in Guillain - Barré syndrome . Other symptom of Miller Fisher syndrome let in respiratory failure and generalised muscle weakness .
How is Miller Fisher Syndrome Diagnosed?
The absolute majority of the patients suffering from Miller Fisher syndrome will have aunique antibodywhich is characteristic of this disease . Other than this , the characteristic symptom of Miller Fisher Syndrome such as of rapid deterioration of the vision and difficulty in walking which are preceded by a diarrheal illness or viral illness helps with the diagnosis . The patient also has difficultness in swallow , slurred language and abnormal facial construction with departure of ability to whistle and smile . Pure Fisher syndrome occur rarely . Most of the affected role evolve the characteristic widespread impuissance of GBS .
neurologic examreveals poor coordination and balance of the hands along with loss of deep tendon reflexes . There is failing of the eye muscles , facial sinew with dilated pupils . Some patients also have a decreased gag physiological reaction on stimulation of the throat .
Nerve conductivity testscan be done which reveal decreased nerve activity , which transmit sensorial info to the brain and spinal cord .
Magnetic Resonance ( MRI ) Imagingof the spinal cord and brain are often normal .
Lumbar Tap : There is elevation of spinal fluid protein .
How is Miller Fisher Syndrome Treated? And What Is The Recovery Period From Miller Fisher Syndrome?
Treatment for Miller Fisher syndrome is similar to that of Guillain - Barré syndrome . Miller Fisher syndrome is often a short lived disorderliness which is good news for patient suffer from it . This condition progresses for a few weeks after which there is an melioration seen . The symptoms of MFS can also point the beginning of GBS where the patient have ventilation difficulty and needs to be hospitalized and kept under observation .
patient role suffering from double-dyed MFS ordinarily find within 2 - 3 months . seldom , in patients who have symptom which cause impairment of routine , other treatments which neutralize or trammel immune system activity are considered such as plasmapheresis or intravenous immune globulin ( IVIg ) .
What is the Prognosis of Miller Fisher Syndrome?
For absolute majority of the patients suffer from Miller Fisher syndrome , the medical prognosis is safe . Many patients recover within 2 to 4 weeks of the onrush of symptom and are almost entirely normal within 6 months . There are some patient who are depart with residual deficits . Rarely there may be a lapse of this disease .
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