What is Ochronosis?
Ochronosis is a pathological shape of the skin and mucosa in which there is a discolouration of the skin and mucous membrane which is normally blue - black in colour . This discolouration take position mostly on the parts of the peel that are unremarkably let on to the sun .
The major reason of Ochronosis is a circumstance calledAlkaptonuria . Alkaptonuria is a transmissible disorder which is autosomal recessive in which the HGD enzyme or homogentisate 1,2 - dioxygenase becomes passive resulting in a build up of homogentisic back breaker within the liver . This acid is spend through the piddle giving it a mordant biased speck .
Another major campaign for Ochronosis is the widespread exercise of skin whitening products . The skin lightening product contain hydroquinone as one of its ingredients and this chemical is the elementary ground for an individual to build up Ochronosis . This is on the nose the reason why ware containing hydroquinone were almost banish from the United States by the FDA . Ochronosis produces lesions on the sunshine exposed parts of the skin which are usually xanthous brown in color . The treatment of this precondition is quite tough and normally supportive concern and prophylactic cadence are used for treatment of Ochronosis .
What Causes Ochronosis?
As stated , the basal causal agency of Ochronosis is employment of cutis whitening product . These products are ordinarily used for knockout intention . These products check hydroquinone as one of its ingredients , even if it is in very small amounts , are responsible for development of lesion get Ochronosis .
sure medical weather condition like mask of pregnancy call for the purpose of compound which hold in hydroquinone and thus are responsible for evolution of Ochronosis . The severity of Ochronosis depends on the length of time that these skin white products are used , the more the length of time the more are the chance of developing Ochronosis .
What are the Symptoms of Ochronosis?
The symptom of Ochronosis are :
How is Ochronosis Treated?
As submit , the treatment of Ochronosis is not easy and is mainly prophylactic . The good way to prevent Ochronosis is by limiting the use of tegument white product which turn back hydroquinone and go towards more raw product . Another manner to prevent Ochronosis is by define the areas of the soundbox that can be expose to direct sunlight .
In some case , cryotherapy has been tried but has not been found to be quite effectual in treating Ochronosis . Use of retinoic acid has been get hold to be effective but not in all cases . The best event for treatment of Ochronosis have been retrieve by exercise of dermocorticoids along with measure to protect the pelt . There have also been other intervention tried like skin peeling and optical maser treatment but they have not grow the want results in treating Ochronosis .
